Biogen has announced an agreement to exclusively license an experimental medicine with potential to treat Alzheimer’s disease (AD) and progressive supranuclear palsy (PSP) from Bristol-Myers Squibb. The drug, known as BMS-986168, is an antibody targeting extracellular tau, the protein that forms the deposits, or tangles, in the brain associated with AD and other neurodegenerative tauopathies […]

Paratek Pharmaceuticals has announced the second positive Phase 3 registration study of omadacycline, which will be used to support marketing applications to the FDA and EMA planned for 2018. The Phase 3 clinical study compares Paratek’s broad spectrum investigational antibiotic, omadacycline, to moxifloxacin in the treatment of patients with community-acquired bacterial pneumonia (CABP). “This successful […]

Sanofi has announced the appointment of Bill Sibold as Executive Vice President Sanofi Genzyme, effective July 1, 2017.  In this role, Mr. Sibold will be a member of the Executive Committee. He succeeds David Meeker, M.D., who will leave the company at the end of June after a distinguished 23-year career with Genzyme and Sanofi. Mr. […]

Sanofi and Regeneron Pharmaceuticals announced that the FDA has approved Dupixent, the first and only biologic medicine approved for the treatment of adults with moderate-to-severe atopic dermatitis (AD), a form of eczema, whose disease is not adequately controlled with topical prescription therapies, or when those therapies are not advisable. Dupixent is a human monoclonal antibody […]

Vertex Pharmaceuticals Incorporated has announced results from two Phase 3 studies of the tezacaftor/ivacaftor combination treatment that showed statistically significant improvements in lung function in people with cystic fibrosis (CF) ages 12 and older who have certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The 24-week EVOLVE study evaluated the combination treatment […]

The Pacific Coast Business Times is reporting that on March 22, Amgen notified nearly 500 employees at their Thousand Oaks facility that they will be re-assigned, relocated, or laid off over the next year and a half. The reassigned employees will be transferred to a new facility in Tampa Bay or to R&D in Cambridge, […]

As reported by Robert Weisman in The Boston Globe, following a report that Burlington-based Flexion Therapeutics is negotiating a sale to French drug giant Sanofi, Flexion shares rose more than 33 percent. Spokeswomen for Sanofi and Flexion — which has a promising knee pain drug up before US regulators — declined to comment. The purchase […]